However, as seen in SS and F0, hepatic fat depots are not enough to induce the progression of NAFLD, nor fibrosis; instead, the increase in IGFBP-7 followed by cellular senescence might be a trigger to progress to NASH, as well as the onset of ECM accumulation, by activating HSC. The gene discussed is IGFBP7; the disease is metabolic dysfunction-associated steatotic liver disease.