One limitation of our study is that we observed only mild-to-moderate fibrosis; further studies in severer stages of fibrosis, cirrhosis, and hepatocellular carcinoma derived from NAFLD are needed in order to establish a complete association between fibrosis, IGFBP-7, and senescence during NAFLD. Here, IGFBP7 is linked to metabolic dysfunction-associated steatotic liver disease.