IGFBP7 and metabolic dysfunction-associated steatotic liver disease: IGFBP-7, a low-affinity IGFBP, was increased in the serum as well as in the liver tissue; interestingly, it was elevated in the serum in bNASH and NASH as well as during fibrosis in F1C and F2, suggesting a role for IGFBP-7 in the progression of NAFLD and the onset of fibrosis in this model.