Homeostatic imbalances associated with CKD lead to changes in the regulation of calcium, phosphorous, PTH, fibroblast growth factor 23 (FGF23) and sclerostin levels, resulting in increased bone demineralisation, often referred to as CKD–mineral and bone disorder (CKD-MBD) [107]. This evidence concerns the gene SOST and Marchiafava-Bignami disease.