CD8A and colorectal carcinoma: To conclude, an improved immunological TME, also associated with a better prognosis in CRC, displays a high level and density of CD45RO+ CD8+ T lymphocytes and Th1 lymphocytes, and high expression of adhesion molecules, while a poor immunological TME often displays low levels of CD45RO+ and CD8+ T lymphocyte and high levels of MDSC, mast cells, Th17 as TILs and CAFs with immunosuppressive features [50,61].