In addition, anti-PD-L1 increased the levels of interleukin-2 (IL-2), tumor necrosis factor-α (TNF-α), and interferon γ (IFN-γ) in the coculture of T cells with CRC cells, while decreasing the levels of IL-1β, IL-10, and TGF-β. This evidence concerns the gene TNF and colorectal carcinoma.