STAT3 and metastatic neoplasm: OncomiR-196b-5p, known to be involved in JAK/STAT3 signaling, was shown to be overexpressed in CRC primary tumors vs. adjacent healthy ones, but also in the serum exosomes of CRC patients vs. healthy donors, and was positively correlated with metastatic disease and lower OS; in vitro studies also correlated it with a lack of response to 5-FU [27].