In this context, finding some reliable blood biomarkers for cognitive impairment in TBI still remains a matter of future perspective, as the changes in exosomal phosphorylated tau, NFL, IL-6, and TNFα might be more related to existent cognitive impairment rather than the history of TBI, as Ganesh and Galetti [56] commented in regards to the findings of Peltz et al. [57]. Here, IL6 is linked to Cognitive impairment.