TGFBR1 and epithelial neoplasm: However, multiple self-healing epitheliomas can usually be distinguished from keratoacanthomas because of the multiple lesions, the earlier ages of the disease onset, and the familial nature of the condition, but a definite diagnosis, however, as in almost all genetic disorders, can be made with genetic testing (such as Transforming Growth Factor Beta Receptor 1 (TGFBR1) mutations).