The study described the effect of genetic polymorphisms found in the IL-6 gene promoter region results on the pro-inflammatory effect of IL-6 levels in patients with hepatitis C. The statistical data found for the polymorphism suggested that IL-6 genotypes in the promoter region may be a significant contributing factor to virus-induced chronic infection and can be compared with the results of Cussigh A et al. in 2011 [4]. This evidence concerns the gene IL6 and hepatitis C virus infection.