Figure 6C,D show that at least in this population, Programmed Cell Death Ligand 1 (PDL1) (also known as CD274, shown in Figure) was not up-regulated in MSI or MSS tumors, but other immune targets like CTLA4 and HAVCR2 were up-regulated in MSI but not in MSS tumor tissue compared to corresponding normal tissue. This evidence concerns the gene HAVCR2 and neoplasm.