IL17A and colorectal carcinoma: For example, the gene-set ANOVA of all the genes involved in the IL-17 signaling pathway shows that on average the genes were up-regulated by 1.19 fold (95% CI 1.167–1.21) in patients with MSI CRC and by 1.15 fold (95% CI 1.13–1.16) in patients with MSS CRC, and this magnitude of up-regulation was significantly higher in the presence of MSI (interaction p = 0.0009).