TIMP1 and obesity due to melanocortin 4 receptor deficiency: Accordingly, we want to assess the profile of MMPs and TIMPs gene expression (MMP-2, 9, 12, 14, TIMP-1,2) in peripheral leukocytes, and plasma levels of MMP-2, 9, TIMP-1,2 of children with simple obesity to find out if they correlate with obese-related parameters [5,6,7].