The ARG2 contribution to cytogenesis in ADPKD is linked with ammonia detoxification in the urea cycle, the production of ornithine used for proline and polyamines synthesis, a decrease in NO synthesis by substrate limitation, a reduction in disponible arginine by affecting the MAPK and mTOR, and apoptosis induction [53,54,55]. The gene discussed is ARG2; the disease is autosomal dominant polycystic kidney disease.