SULF2 influences fibrotic liver disease by interacting with the TGF-β1/Smad pathway, and it appears that Transforming Growth Factor Beta Receptor 3 (TGFBR3) plays a significant role in mediating the activation of the TGF-β1 signaling pathway by SULF2 [47]. The gene discussed is TGFBR3; the disease is liver disorder.