IGHE and allergic disease: The genes associated with mucin production (GAL3ST2) [53], leukotriene synthesis (GPX4) [54], Th2-mediated allergic asthma (PTBP1, ZFPM1, SBNO2, and EGFL7) [52,55,56,57], and IgE mediated allergy (PAK2) [58] were also represented in our polygenic prediction models of ICS response.