According to De Kloet et al, SNPs in the glucocorticoid receptor (GR) impact the metabolic profile and cardiovascular parameters: ER22/23EK, with a favorable profile (decreased the response to cortisol), and N363S together with Bcl1, with a less advantageous one (they increased the cortisol responses to various types of stress, causing immunosuppression in the patient and a predisposition to infection) [28]. This evidence concerns the gene NR3C1 and infection.