Li et al. reported that PRDM1 induces cancer immune evasion via ubiquitin-specific peptidase 22 (USP22), Spi-1 proto-oncogene (SPI1), and programmed death ligand 1 (PDL1) while also continuing their previous works on PRDM1 resultantly finding it increased PDL1 expression in liver cancer. The gene discussed is USP22; the disease is cancer.