Zeng et al. reported that DNA methylation is an important target in stomach cancer prediction and treatment while discovering that aberrantly methylated genes with potential for diagnosis and prognosis included secreted frizzle-related protein 2 (SFRP2), thrombospondin 1 (THBS1), ubiquitin C-terminal hydrolase L1 (UCHL1), SRY-box transcription factor 17 (SOX17), APC regulator of WNT signaling pathway (APC), E-cadherin, Ras association domain family member 1 (RASSF1A), ring finger protein 180 (RNF180), and spartin (SPART, SPG20) [42]. This evidence concerns the gene RNF180 and gastric neoplasm.