As the role of PRDM1 in GI cancers using systematic methodology has yet to be explored, we performed such bioinformatic analysis and found PRDM1 was increased in stomach cancer and this increment predicted poor prognosis; subsequently, we investigated the mechanism and therapeutic applications for PRDM1-high stomach cancer as well as briefly reviewing GI cancers and the potential roles of PRDM1 within. The gene discussed is PRDM1; the disease is gastric neoplasm.