The Cancer Genome Atlas Network reported that typical oncogenes and tumor suppressors for this cancer type include cyclin-dependent kinase inhibitor 2A (CDKN2A), tumor protein p53 (TP53), phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA), notch receptor 1 (NOTCH1), and chromatin regulator lysine methyltransferase 2D (KMT2D) [35], while Shen et al. reported that PRDM1 is negatively associated with microsatellite instability in this cancer type [36]. The gene discussed is PIK3CA; the disease is cancer.