BAX and Familial prostate cancer: In addition to the four miRNAs validated using RT-qPCR, miR-193a-5p, which was identified via sequencing (Table 4) but not validated in this study, was also related to significant suppression of oxidative stress-induced apoptosis, as revealed by increased anti-apoptotic protein (Bcl-2) and decreased proapoptotic Bax expression in prostate cancer cells [56].