In addition, feeding rats with Bifidobacterium longum freeze-dried culture medium could significantly reduce the volume of colon tumors, reduce the incidence of colon cancer and inhibit the cell proliferation induced by carcinogens (azomethane), the activity of ornithine decarboxylase associated with colon adenoma and cancer, and the expression of ras-p21 cancer protein [22]. Here, ODC1 is linked to colonic neoplasm.