In the case of Alistipes, a new genus of Alistipes emerged in the MD and HD group after long-term gavage of this health drink (Figure 6D), which is considered to be rarely involved in human diseases [38] and may be negatively associated with human obesity [39], mainly due to the positive correlation between Alistipes and serum ANGPTL4 and adropin. The gene discussed is ENHO; the disease is obesity due to melanocortin 4 receptor deficiency.