It might be seen that the sodium hyaluronate health drink could stimulate the release of immune factors in mice, and among which the IL-6 and TNF-α content in immunocompromised mice gradually returned to normal levels after gavage of the sodium hyaluronate health drink, which indicated that long-term gavage of this sodium hyaluronate health drink could effectively restore the immunodeficiency caused by cyclophosphamide. This evidence concerns the gene TNF and immune system disorder.