As noted, proteolytic processing of Reelin is critical for the maintenance of granule cell lamination in the DG and the regulation of the GCD in the model of TLE [43,44,45,46,47,48,49], a chronic form of focal epilepsy that is often associated with SRS and characteristic hippocampal sclerosis [4,37,50,51]. Here, RELN is linked to focal epilepsy.