VIP and encephalopathy, progressive, early-onset, with brain edema and/or leukoencephalopathy: VIP interneuron dysfunction is also implicated in three prominent neurodevelopmental disorders, Rett syndrome, Dravet Syndrome, and Down’s syndrome [25,26,27], and may contribute to enhanced seizure susceptibility and epileptogenesis associated with altered synaptic plasticity in these developmental disorders as in other acquired epilepsies [2,28,29,30].