Among the genes that were notably down-regulated (NDUFA4, COX5B, COX6C, NDUFA3, NDUFB4, COX5A, COX6A2, NDUFA6, COX8A and ATP5MC1), only NDUFA4 has been previously identified in connection with ALS. This evidence concerns the gene NDUFB4 and amyotrophic lateral sclerosis.