However, Ye et al. reported no significant differences in serum levels of activin A, BMP4 or BMP6 between healthy individuals and FOP patients, nor between FOP patients with active flare-ups or in remission, suggesting that activin A, BMP4 and BMP6 may be instigators for flare-ups in FOP, but not biomarkers for FOP disease activity [107]. This evidence concerns the gene BMP4 and fibrodysplasia ossificans progressiva.