As such, we cannot rule out off target effects from Pten elimination in Plp1- and Calb2-expressing cells throughout the body; (2) only one injury model, DSS-colitis, was tested and our observations may not be applicable to other injury types, such as infectious or ischemic; (3) although we had a satisfactory sample number in all groups, we were only able to inspect two timepoints after DSS-colitis, early (3–4 days) and late (3–4 weeks). The gene discussed is PTEN; the disease is colitis.