Moreover, MUC1 increases PD-L1 expression directly at the transcriptional level, induces primary healthy monocytes to differentiate into macrophages with a tumor-associated macrophage M2-like (TAM2) phenotype, and decreases MCP1, IFN-gamma, and GM-CSF expression [33,34,35]. The gene discussed is MUC1; the disease is neoplasm.