These results, along with the high expression levels of TKT, PPP intermediates, and G6PDH, point to a higher rerouting of the sugar metabolism toward this pathway to support redox homeostasis and anabolic processes, particularly in MUC1H ccRCC Alteration of lipid metabolism represents another important hallmark of ccRCC. This evidence concerns the gene H6PD and nonpapillary renal cell carcinoma.