TARDBP and Alzheimer disease: Neurodegenerative diseases are most commonly characterized by the aggregation of misfolded proteins due to improper post-translational modification of proteins like TDP-43 in amyotrophic lateral sclerosis/frontal temporal lobe dementia (ALS/FTLD), α-synuclein (α-syn) in Parkinson’s disease (PD), and β-amyloid (Aβ) in Alzheimer’s disease (AD) [1,2,3].