During cerebral ischemia, the activation of inflammasomes leads to the activation of caspase-1, which cleaves pro-IL-1β and IL-17 to produce IL-1β and IL-17, respectively, both of which are key inflammatory cytokines, inducing neuronal death along with other pro-inflammatory factors during pyroptosis [44]. The gene discussed is CASP1; the disease is Cerebral ischemia.