Key: 4-HNE = 4-Hyfroxy-2-nonenal, ADP = Adenosine diphosphate, AIF = Apoptosis-inducing factor, PARP = Poly(ADP-ribose) polymerase, ATP = Adenosine triphosphate, DAMPs = Damage-associated molecular patterns, GPX4 = Glutathione peroxidase 4, GSDM-D = Gasdermin D, IL = Interleukin, IS = Ischemic stroke, MDA = Malondialdehyde, MLKL = Mixed-lineage kinase domain-like protein, MLKLp = Phosphorylated MLKL, NLRP = NOD-like receptor pyrin domain-containing, PS = Phosphatidylserine, RIPK = Receptor-interacting protein kinases, ROS = Reactive oxygen species, TNFR1 = Tumour necrosis factor receptor 1. The gene discussed is GPX4; the disease is Stroke.