Tan et al. demonstrated that irisin treatment attenuated LPS-mediated cardiomyocyte death and myocardial dysfunction by inhibiting dynamin-related protein 1 (DRP1)-related mitochondrial fission through the Jun N-terminal—Large Tumor Suppressor 2 kinase (JNK-LATS2) signaling pathway in LPS-induced sepsis in mice [28]. The gene discussed is LATS2; the disease is Sepsis.