Circulating irisin (AUROC > 0.72), CRP (AUROC > 0.78), and procalcitonin (AUROC > 0.71) at enrollment presented superior discriminative ability (as expressed by areas under the ROC curves/AUROC) compared to IL-6 (AUROC > 0.69), IL-10 (AUROC > 0.68), and suPAR (AUROC > 0.64) in distinguishing sepsis from septic shock; nevertheless, the comparison of ROC curves did not yield any statistically significant results (p > 0.05 derived from the DeLong test) (Figure 3). This evidence concerns the gene FNDC5 and Sepsis.