According to studies of lung cancer model survival after radiation therapy, compared to surviving cells that received the same dose of radiation (6 times), lung cancer cells that survived after 3 doses of radiation therapy strongly expressed stem-related signals, such as CD44, CD133, and OCT4, and were associated with increased senescence-related SA-β-Gal staining [47]. The gene discussed is PROM1; the disease is lung carcinoma.