IL6 and neoplasm: On the one hand, IL-1α, IL-6, and IL-8 can mediate the recruitment of M1-like macrophages, T helper 1 cells, and natural killer (NK) cells into the tumor microenvironment [96], thus promoting the clearance of senescent cells themselves and exerting a bystander effect in the tumor microenvironment, which may induce non-senescent tumor cells to progress towards a senescent outcome.