It has been reported that, compared to those of young AML patients, mutations in epigenetic regulatory factors such as DNMT3A, TET2, SRSF2, and ASXL1 were more common among elderly AML patients and were accompanied by an increase in the frequency of changes in DNA repair- and splicing-related genes [70]. This evidence concerns the gene ASXL1 and acute myeloid leukemia.