In summary, results of this study demonstrate that DIM-3,5 and DIM8-3,5 analogs bind both NR4A1 and NR4A2, activate NR4A1- and NR4A2-dependent transactivation, and, like other DIM analogs, these compounds are cytotoxic to colon and glioblastoma cells [32,36]. The gene discussed is NR4A2; the disease is glioblastoma.