NR4A1 and breast cancer: In previous studies, we have shown that the CDIM compounds inhibit the growth of multiple cancer cell lines and, in breast cancer cells, the knockdown of NR4A1 abrogated the growth inhibitory effects of DIM-3-Cl-5-OCH3, DIM-3-Cl-5-OCF3, DIM-3-Cl-5-CF3, and DIM-3-Br-5-OCF3 [33,34,35].