CD4 and neoplasm: In addition, we will also investigate the applications of dual NR4A1/NR4A2 ligands on responses in which both receptors play similar roles, and this includes neuroinflammation and immune cell exhaustion [47,48,49,50], where it has recently been reported that DIM8-3-Cl-5-OCH3 enhances CD8+ T-cell/CD4+ T-cell ratios in tumor-infiltrating lymphocytes [32].