For example, in mouse models of metabolic disease, the NR4A1 ligand, Csnb, elevated serum glucose levels [26], whereas structurally related ethyl-2-[2,3,4-trimethoxy-6-(1-octanoyl) phenyl acetate (TMPA) decreased blood glucose levels in diabetic mouse models [30]. This evidence concerns the gene NR4A1 and metabolic disease.