For instance, upon IFN-γ stimulation, the solo-LTR12F switches on the full-length HERV-K102 in patients with cutaneous leishmaniasis [124], and IFN-γ and IFN-α together significantly activate HERV-K18 in T cells of patients with type-1 diabetes [126]. This evidence concerns the gene IFNA1 and type 1 diabetes mellitus.