AFP and hepatocellular carcinoma: In the study by Kim et al., the authors showed that the HCC-driver oncogenic lncRNA candidates, EV-MALAT1, EV-DLEU2, EV-HOTTIP, and EV-SNHG1, were detected in serum EVs and were promising as a panel of biomarkers in the diagnosis of HCC and showed superior sensitivity compared to Alpha-fetoprotein (AFP) [151].