These two compounds were tested on the Drosophila PD strain LRRK2 loss of function (LRRK) compared to wild type (w1118) in terms of physiological and brain morphological parameters that are severely compromised in mutant flies, such as longevity, motor activity, integrity of brain dopaminergic neurons, brain mitochondria and synapse abnormalities. Here, LRRK2 is linked to Parkinson disease.