In this study, p21-overexpression partially recapitulated CORT-induced phenotypes, including ROS accumulation, reduction in hippocampal neurogenesis and dendritic branching, and anxiety-like behaviors (Figure 3); and antioxidants partially rescued the p21-overexpression-induced phenotypes (Figure 4), indicating that ROS accumulation is a direct consequence of p21 up-regulation. Here, CDKN1A is linked to Anxiety.