HMOX1 and acute kidney injury: Finally, HSP32 or heme-oxygenase (HO-1), which is an enzyme whose products, CO and biliverdin, are potent ROS scavengers, has also been shown to increase in the context of certain stressors such as increased temperatures, heavy metal intoxication, and ROS exposure, which (as described previously) are key drivers of AKI in the context of temperature stress [137].