However, beyond cancer, genetic diseases, such as Meier–Gorlin syndrome, a form of microcephalic primordial dwarfism, and Coats plus syndrome (also called Cerebro retinal Microangiopathy with Calcifications and Cysts (CRMCC)), a multi-organ symptom, including the brain, eye, and gastrointestinal tract, have mutations in central players of the initiation of DNA synthesis, such as MCM2-7, CDC45, and the CST complex [28,82,155,163,168]. Here, CDC45 is linked to Coats plus syndrome.