CDC45 and hereditary disease: Interestingly, mutations in ORC subunits, CDC6 (cell division cycle 6), CDT1 (chromatin licensing and DNA replication factor 1), Donson, MCM2-7, CDC45, and other replication initiation factors have been found to be the cause of genetic diseases, such as Meier–Gorlin syndrome, highlighting the importance of understanding the mechanism of initiation in humans [9,22,24,25,26,27,28].