Their target genes, including FBXO32 (also known as MAFbx/Atrogin-1), TRIM63 (also known as MuRF1), CTSL, and BNIP3, are commonly upregulated in various models of skeletal muscle atrophy [56,57], and their upregulation accelerates protein degradation [54,58]. The gene discussed is BNIP3; the disease is muscular atrophy.