According to literature data, the detectability of PTPN11 variants relative to all identified variants in the cohort with Noonan syndrome (NS) varies widely and ranges from 20% to 60% with a median of 36% [21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40]. The gene discussed is PTPN11; the disease is Noonan syndrome.