Conversely, an individual with widespread clinical manifestations of TSC (renal AMLs, angiofibromas, fibrous cephalic plaque, enamel pits, retinal hamartomas, cortical tubers, and SEN) was found to have an isolated somatic TSC2 pathogenic variant in renal AML tissue, with none in skin fibroblasts or saliva [116]. The gene discussed is TSC2; the disease is tuberous sclerosis.