In 22q11.2DS patients, CNVs of the genes GPR98 (G-protein-coupled receptor 98) [93], KANSL1 (KAT8 regulatory NSL complex subunit 1 gene) [94] and SC2A3 (solute carrier family 2 facilitated glucose transporter member 3) [95] have been described as risk factors for congenital heart anomalies. This evidence concerns the gene ADGRV1 and congenital heart disease.