Looking at the pattern of variants per patient (Table 1), we saw that patient ALS-30 had three variants in the FUS gene, one characterized via PolyPhen-2 as “probably damaging” [c.162G>T (p.S28I)] and two as “benign” [c.626A>C (p.M183L) and c.806C>T (p.R243C)]. This evidence concerns the gene FUS and amyotrophic lateral sclerosis.