Interestingly, in the French literature, Soukarieh et al. [41] recently identified two variations, c.-68G>A and c.-79C>T, at the 5′ untranslated region of ENG in unrelated HHT patients, shedding new light on the role of upstream open-reading frames in the expression regulation of ENG. This evidence concerns the gene ENG and hereditary hemorrhagic telangiectasia.