Mesenchymal stem cells as well as tumor-associated stroma cells (TASCs) are known to be important components in the microenvironment of tumors and BM-MSCs have been shown to modulate cell growth and survival through cell–cell contact and cytokine production, including IL-6, IL-17, and tumor necrosis factor (TNF) [59]. The gene discussed is TNF; the disease is neoplasm.