BAP1 and uveal melanoma: Table 4 shows that chromosome 3 hosts three novel genetic variants that cause uveal melanoma. The BAP1 gene undergoes alteration on exon 17. Therefore, children with this variant are at risk of unregulated cell growth in the ocular cells, causing malignancy development. Similarly, SF3B1 and E1F1AX are genetic variants that predispose a child to uveal melanoma. SF3B1 drives a frameshift deletion on exon 15. This deletion causes an abnormality in gene SF3B1, making the carrier susceptible to uveal melanoma.