MSH6 and plexiform neurofibroma: Table 4 shows that mutations in NFI and BRAF genes cause alterations in chromosomes 17 and 7, respectively. In both events, the chromosomal alterations occur due to deletions of crucial DNA fragments that ensure normal functionality of NF1 and BRAF genes. Thus, these genes are unable to synthesize proteins that regulate cell growth. As a result, malignant tumors begin forming in the affected person’s ocular cells. Beyond inheriting these biomarkers, plexiform neurofibroma can be driven by DPH2 and MSH6 mutations.