For example, in a study including 26 patients with stage II-IV HNSCC, it was shown that 100% of primary tumors with the low E-cadherin and high Vimentin signature developed distant metastases compared to a 44% metastasis rate for primary HNSCC tumors with an incomplete or null EMT signature [33]. Here, CDH1 is linked to head and neck squamous cell carcinoma.