In a study by Bos et al. (2021) analyzing Apolipoprotein E gene-environment interaction using data from the UK Biobank (345,659 whites without a history of coronary heart disease), carriers of the ε2 allele (rs7412) had the best overall survival rate in the stud, while the ε4 allele (rs429358) holders had the worst prognosis [12]. The gene discussed is APOE; the disease is coronary artery disorder.