Liang et al. further reported that by binding to CREB-binding protein (CBP), CASC9 can recruit CBP to the promoter of laminin subunit gamma-2 (LAMC2), subsequently activating the focal adhesion kinase (FAK)-phosphoinositide-3-kinase (PI3K)/protein kinase B (Akt) pathway to promote ESCC metastasis [30]. This evidence concerns the gene CREBBP and esophageal squamous cell carcinoma.