Mechanistically, LINC00337 recruits E2F transcription factor 4 (E2F4) to binding sites within the promotor of the targeting protein for Xenopus kinesin-like protein 2 (TPX2), which was previously found to be related to cell proliferation and a poor prognosis in ESCC patients [100]. This evidence concerns the gene E2F4 and esophageal squamous cell carcinoma.