The lncRNA EZR-AS1 can complex with RNA polymerase 2 and recruit SET and MYND domain containing 3 (SMYD3) to the SMYD3 binding site within the GC-rich region downstream of the EZR promoter, inducing EZR transcription to enhance ESCC cell migration [64]. Here, EZR is linked to esophageal squamous cell carcinoma.