Bladder cancer is no exception, as LDHA is increased in the cells and boosts glycolysis, proliferation, and invasion [49], and serum levels can be used as a biomarker and are associated with decreased overall and progression-free survival, particularly in non-urothelial carcinoma of the bladder cancers such as squamous bladder cancer [50]. This evidence concerns the gene LDHA and urothelial carcinoma.