This protein is a disulfide isomerase expressed in the endoplasmic reticulum that regulates protein folding and is related to the initiation of carcinogenesis, its progression, and resistance to therapy [36], and is overexpressed in bladder cancer cells and can be related to the local spread of cancer, and the secretion of this protein by bladder cancer cells can be used as a biomarker [37]. This evidence concerns the gene TXNDC15 and urinary bladder cancer.