A significant decrease in Cas-3-positive cells (p = 0.032) was observed in the Stroke + Kr group compared with that in the Stroke + N2 group, with a distribution density (the ratio of the number of Cas-3-positive cells to the total lesion area) of 3672 (3158; 4448), with a.u./mm2 vs. 5712 (4512; 8574) and a.u./mm2 in the experimental and control groups, respectively (Figure 3f). Here, EFS is linked to stroke disorder.