Similar observations occurred in experimental models of epilepsy, including loss of limbic-projecting serotonergic neurons from the median raphe nucleus [26] and deterioration of dopaminergic projections from the VTA to the nucleus accumbens [27] coupled to decreased vesicular monoamine transporter 2 in the temporal cortex and hippocampus [28]. This evidence concerns the gene SLC18A2 and epilepsy.