Similar observations occurred in experimental models of epilepsy, such as (1) selective loss of GABAergic septal projections to the limbic cortex [51], (2) enrichment in cholinergic neurons in the median septum together with proliferation of cholinergic boutons and fibre sprouting in the hippocampus [52], (3) loss of limbic-projecting median raphe serotonergic neurons [26], decreased serotonin levels [38], and (4) decline of VTA dopaminergic projections to the nucleus accumbens [27] coupled to decreased vesicular monoamine transporter 2 in the temporal cortex and hippocampus [28]. This evidence concerns the gene SLC18A2 and epilepsy.