APOE and Alzheimer disease: From apolipoprotein E gene allele E4 (APOE4, high sporadic AD risk) and allele E3 (APOE3, lower AD risk) carrying patient-derived iPSCs, BBB cells [induced brain endothelial-like cells (iBECs)] and astrocytes (iAstrocytes) were generated to establish monocultures and co-cultures of human sporadic AD and control BBB cells, aiming at assessing the effects of FUS+MB on BBB cell phenotype.