There was also an unexpected increase in the incidence of T2DM in the subgroup of patients with ACS who were homozygous for the rs2081687 T, rs9297944 G, rs10504255 G, and rs10107182 C alleles of the CYP7A1 gene, suggesting that such gene variants enhance the development of coronary complications in diabetic patients. Here, CYP7A1 is linked to type 2 diabetes mellitus.