In addition, Wang et al. reported that rs9297994 G/A and rs10107182 C/T SNPs seem to interact with the rs3808607 G/T polymorphic site to determine CYP7A1 mRNA expression in human livers [5], but little is known about the effect of these genetic variants on the risk of developing coronary heart disease. This evidence concerns the gene CYP7A1 and coronary artery disorder.