AGER and systemic lupus erythematosus: It is worth noting that the role of sRAGE in SLE is not clear, since although most studies have found lower sRAGE levels in SLE vs. healthy controls (HC) [23,24,25,26,27,28], as well as some inconsistent relationships with some SLE characteristics or indexes, three studies have described opposite results linking higher sRAGE levels with increased inflammation [20,29,30].