A statistically significant positive association was observed with the presence of anti-Ro52 antibodies in the blood test results, in non-Caucasian ethnicities, in the SDI (only in the OLS model), as well as densitometric osteoporosis, taking dyslipidemia drugs, CRP and IL-6 values, IL-6 pathological values (>7 pg/mL), and male sex. The gene discussed is TRIM21; the disease is osteoporosis.